POTENSI EKSTRAK TERIPANG (Holothuria leucospilota) SEBAGAI ANTI TUKAK LAMBUNG PADA MENCIT (Mus musculus) YANG DIINDUKSI MINUMAN KERAS (MIRAS) OPLOSAN

POTENCY OF SEA CUCUMBER (Holothuria leucospilota) EXTRACT AS AN ANTI-GASTRIC ULCER IN MICE (Mus musculus) INDUCED BY MIXED ALCOHOL

Gastric ulcers a disease that’s often found in the community can be caused by alcohol consumption and can cause death. Indonesia has abundant sea cucumber (Holothuria leucospilota), rich in antioxidant compounds that potentially preventing and curing gastric ulcers without side effects, but not utilized optimally. The study aimed to examine the potential effect and determine the most optimal dose of sea cucumber extract as an anti-gastric ulcer in mice induced by mixed alcohol based on the pH of the gastric fluid and gastric ulcer index. This study had 7 groups with complete random design, normal control, negative control, positive control, 4 treatment groups were treated extract of sea cucumber with dose 0,61 mg/20 g BW, 1,03 mg/20 g BW, 1,45 mg/20 g BW, dan 1,87 mg/20 g BW. Groups were induced by mixed alcohol for 8 days and treated with sea cucumber extract for 12 days. Sea cucumbers were obtained from random sampling. Data on gastric fluid pH and gastric ulcer index were taken based on the number and the severity of ulcers. The gastric fluid pH was analyzed descriptively, and the gastric ulcer index was analyzed using the Kruskal-Wallis test, then Mann-Whitney test. The results showed that sea cucumber extract was able to restore the pH of the gastric fluid of mice to normal and could reduce the gastric ulcer index significantly. The most optimal dose in curing gastric ulcer is 1.87mg/20g BW.