Pengaruh Kurkumin Terhadap Kadar Nuclear Factor-kappa Betta (NF-κB), Kadar Tumor Necrosis Factor-Alpha (TNF-α), Intensitas Nyeri, dan Range of Motion (ROM) Setelah Latihan Fisik Dengan Intensitas Tinggi

Effect of Curcumin on Nuclear Factor-kappa Betta (NF-κB) Levels, Tumor Necrosis Factor-Alpha (TNF-α) Levels, Pain Intensity, and Range of Motion (ROM) After High-Intensity Physical Exercise

ABSTRAK

Ayubi, Novadri, 2023. Pengaruh Kurkumin Terhadap Kadar Nuclear Factor-kappa Betta (NF-κB), Kadar Tumor Necrosis Factor-Alpha (TNF-α), Intensitas Nyeri, dan Range of Motion (ROM) Setelah Latihan Fisik Dengan Intensitas Tinggi. Promotor: Prof. Dr. Nining Widyah Kusnanik, M.Appl.Sc., Co-Promotor: Dr. Lilik Herawati., dr., M.Kes.

Kata Kunci: Kurkumin; Inflamasi, Intensitas Nyeri, ROM, Exercise.

Penelitian ini bertujuan untuk menganalisis efek kurkumin terhadap kadar NF-κB, kadar TNF-α, intensitas nyeri dan ROM setelah latihan fisik intensitas tinggi.

Penelitian eksperimental ini menggunakan rancangan pre and post control group design. Subjek penelitian dipilih menggunakan teknik random sampling dan kemudian subjek dibagi menjadi 2 kelompok yaitu kelompok (K1) dengan pemberian placebo dan kelompok (K2) dengan pemberian kurkumin dengan dosis 400 mg. Sebanyak 20 orang pria sehat berusia rentangan 20-30 tahun berpartisipasi dalam penelitian ini. Intervensi dilakukan 24 jam setelah latihan fisik intensitas tinggi, Data dalam penelitian ini diambil sebelum dan sesudah intervensi. Pengukuran kadar NF-kB dan TNF-a menggunakan metode ELISA, pengukuran intensitas nyeri menggunakan (VAS), pengukuran ROM  menggunakan goniometer.  

Hasil penelitian ini melaporkan bahwa kelompok yang diberi kurkumin setelah latihan fisik intensitas tinggi mampu menurunkan kadar NF-kB, TNF-α dan intensitas nyeri secara signifikan (p<0.05) dibandingkan dengan kelompok yang diberi placebo. Selain itu, terjadi peningkatan ROM pada kelompok yang diberi kurkumin secara signifikan (p<0.05) dibandingkan kelompok kontrol.

Dapat disimpulkan bahwa pemberian kurkumin dengan dosis 400 mg setelah 24 jam latihan fisik intensitas tinggi mampu menurunkan kadar NF-kB, TNF-α, intensitas nyeri dan mampu meningkatkan ROM.

ABSTRACT

Ayubi, Novadri, 2023. Effect of Curcumin on Nuclear Factor-kappa Betta (NF-κB) Levels, Tumor Necrosis Factor-Alpha (TNF-α) Levels, Pain Intensity, and Range of Motion (ROM) After High-Intensity Physical Exercise. Promotor: Prof. Dr. Nining Widyah Kusnanik, M.Appl.Sc., Co-Promotor: Dr. Lilik Herawati., dr., M.Kes.

Keywords: Curcumin; Inflammation, Pain Intensity, ROM, Exercise

This study aims to analyze the effect of curcumin on NF-κB levels, TNF-α levels, pain intensity, and ROM after high-intensity physical exercise.

This experimental study used a pre and post-control group design. The research subjects were selected using a random sampling technique and then the subjects were divided into 2 groups, namely group (K1) with placebo administration and group (K2) with curcumin administration with a dose of 400 mg. As many as 20 healthy men aged between 20-30 years participated in this study. The intervention was carried out 24 hours after high-intensity physical exercise. The data in this study were taken before and after the intervention. Measurement of NF-kB and TNF-α levels using the ELISA method, measuring pain intensity using (VAS), measuring ROM using a goniometer.

The results of this study reported that the group given curcumin after high-intensity physical exercise was able to significantly reduce levels of NF-kB, TNF-α, and pain intensity (*p<0.05) compared to the group given a placebo . In addition, there was an increase in ROM in the curcumin-treated group significantly (*p<0.05) compared to the control group.

It can be concluded that the administration of curcumin at a dose of 400 mg after 24 hours of high-intensity physical exercise can reduce levels of NF-kB, TNF-α, and pain intensity and can increase ROM.